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# E222 purchase order transactions

 

 

 

 

 

 

 

 

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An E222 Purchase Order is a digital document used to initiate the purchase of Schedule II controlled substances in compliance with DEA (Drug Enforcement Administration) regulations. It is part of the CSOS (Controlled Substance Ordering System) and serves as the electronic equivalent of the traditional DEA Form 222. The E222 Purchase Order contains a DEA-issued digital certificate that authenticates the buyer’s identity, verifies compliance with controlled substance regulations, and confirms the order is within permitted quantity limits. It also includes encrypted, digitally signed order data to ensure integrity and authenticity, along with information about the controlled substances being purchased, such as item codes, quantities, and supplier details. The file must be kept in its original form, as any modification can invalidate the signature and potentially delay order processing. By using the E222 Purchase Order, trading partners can securely exchange controlled substance orders through compliant B2B integrations, reduce paperwork, and speed up the ordering process. Its secure, validated format helps maintain regulatory compliance, protect supply chain integrity, and ensure timely fulfillment of sensitive products.



 

 

 

 

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